-AOD 9604
It is a modified form of amino acids 176-191 of the GH polypeptide. Investigators at Monash University discovered that the fat-reducing effects of GH appear to be controlled by a small region near one end of the GH molecule. This region, which consists of amino acids 176-191, is less than 10% of the total size of the GH molecule and appears not to affect growth or insulin resistance. It works by mimicking the way natural Growth Hormone regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified Growth Hormone. Like Growth Hormone, AOD 9604 stimulates lipolysis (the breakdown or destruction of fat) and inhibits lipogenesis (the transformation of nonfat food materials into body fat).
Benefits:
- Reduces body fat.
- Regulates fat metabolism.
- Stimulates Lipolysis.
- Inhibits Lipogenesis.
- Triggers fat release
-MOTS-C
It is a short open reading frame (sORF) 16 amino-acid peptide. MOTS-C has endocrine like effects on muscle metabolism, insulin sensitivity, and weight regulation. It regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle.
MOTS-C has been shown to target the skeletal muscle and enhance glucose metabolism. As such, MOTS-C has implications in the regulation of obesity, diabetes, exercise, and longevity, representing an entirely novel mitochondrial signaling mechanism to regulate metabolism within and between cells.
MOTS-C assists with gene expression and cellular metabolism. It appeared to stimulate glucose utilization by increased glucose clearance. Coordinates cellular glucose, mitochondrial, and fatty acid metabolism.
MOTS-c prevents HFD-induced obesity by increasing energy expenditure, including heat production, improving glucose utilization and insulin sensitivity. Reduced fat accumulation may be a result of robust carbohydrate usage that reduces fatty acid synthesis
Benefits:
- Regulates insulin sensitivity and maintain metabolism.
- Stimulate fatty acid oxidation.
- Enhance glucose uptake and clearance into muscle.
- Stimulate glucose utilization.
- Coordinates cellular glucose, mitochondrial, and fatty acid metabolism.
- Increased energy expenditure and heat production.
- Reduction of fat accumulation.
-Tetradecyl Thioacetic Acid
Otherwise known as TTA, is what is known as a PPAR-alpha activator. It is an omega-3 fatty acid. PPARa activation can be seen as protecting the body from excess fats. PPARa tends to clear fats from the blood into muscle or liver cells and encourage them to be burnt for energy in these locations. The clearing of fat from the blood causes a drop in lipoproteins and alowering of LDL cholesterol. The burning of fats causes either fat burning or reduced-fat gain. TTA can also decrease blood pressure and exert an anti-oxidant effect, the four mechanisms make this a cardioprotective compound. TTA has been shown to reduce body weight gain (primarily by reducing adiposity), provide beneficial effects on insulin resistance and elevated plasma glucose levels, and improve dyslipidemia in pre-clinical models of obesity and diabetes.
Benefits:
- Weight loss
- Decrease LDL Cholesterol
- Improve insulin resistance
- Decreased the epididymal adipose (fat) tissue mass
- Increase fatty acid transport, uptake, and oxidation
- Lower blood pressure
- Reduction in Hemoglobin A1c and fructosamine
- Cardioprotective
-Tesofensine
It is a dopamine, serotonin, and noradrenaline (triple) reuptake inhibitor originally developed to treat neurological disorders such as Parkinson’s disease (PD) and Alzheimer’s disease. Although tesofensine failed to demonstrate efficacy in PD trials, overweight participants achieved significant weight loss. Tesofenesine was changed from development for these applications as it showed limited efficacy. It did show consistent weight loss especially in overweight or obese patients. Tesofensine, an inhibitor of presynaptic uptake of the neurotransmitters serotonin, noradrenaline, and dopamine, acts primarily as an appetite suppressant with simultaneous effects on fat oxidation and resting energy expenditure. Clinical trial data suggests it may potentially achieve more significant reductions in weight than that seen with currently approved weight loss agents.
Benefits:
- Significantly affected appetite
- Reduction in expected next meal size
- Decreased desires for sweet, fatty, or salty foods
– Tirzepatide
It is a once-weekly GIP(glucose-dependent insulinotropic polypeptide) receptor, and GLP-1 (glucagon-like peptide-1) receptor agonist, representing a new class of medicines studied for the treatment of obesity. Tirzepatide is a single peptide that triggers the body’s receptors for GIP and GLP-1, two natural incretin hormones. Cyanocobalamin will help increase energy.
GIP has decreased food intake and increased energy expenditure, resulting in weight reductions. Combined with a GLP-1 receptor agonist, it has a more significant effect on glucose and body weight effects.
Benefits:
- Substantial A1C reductions.
- Boosted weight loss.
- Improvements in cardiometabolic measures.
- Reduced appetite
-CJC1295/Ipamorelin
It is a combination of two peptides, a GHRH (growth hormonereleasing hormone) and GHRP (growth hormone releasing peptide), all in one. Both of these peptides work together synergistically to amplify the pulse to promote the release of growth hormone.
The primary purpose of CJC-1295 is to boost protein synthesis levels and help fuel the growth of muscle tissues in the body. CJC 1295 was developed to treat diseases.
Benefits:
- Improve sleep quality.
- Increase cognitive function.
- Decrease body fat.
- Quicker recovery times post-injury.
- Increased muscle mass.
- Increase in strength
-MK-677
It is a hormone secretion compound that stimulates the pituitary gland to increase the production of human growth hormone. Ibutamoren is a long-acting, orally active, selective, and non-peptide
agonist of the ghrelin receptor and a growth hormone secretagogue, imitating the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin.
Benefits:
- Increase IGF-1 Levels in as little as two weeks.
- longer REM sleep and shorter sleep latency.
- Increase fat-free muscle mass.
- Decrease body fat percentage.
- Stronger bones.
- Improved endurance
- Increase nitrogen levels in the body.
- Reversal of nitrogen wasting.
-SERMORELIN GRF 1-29
GH secretagogues can promote pituitary health and function during aging. Sermorelin, an analog of naturally occurring growth hormone-releasing hormone (GHRH) whose activity declines
during aging, may presently offer a more immediate and better alternative to rhGH for GHRT in aging. Pituitary recrudescence resulting from sermorelin helps slow the cascade of hypophyseal
hormone failure during aging, thereby preserving not only youthful anatomy but also youthful physiology. Sermorelin stimulates the patient’s pituitary gland by binding to specific receptors to
increase the production and secretion of endogenous HGH.
Benefits:
- Improvements in wellbeing andlibido.
- Augmented restful sleep leads to better cognitive functions.
- Refined skin tone with stronger hair and nails.
- Decrease in mean systolic blood pressure.
- Improvement in fat loss and lean mass gains.
- Increased endurance and strength.
- Significant increases in GH release two hours after administration.
-Sermorelin Plus
It has all of the benefits of Sermorelin plus the added benefits of Ipamorelin and Glycine. Ipamorelin is a synthetic pentapeptide, a selective agonist of the ghrelin/ GHS receptor pathway. Ipamorelin selectively binds the GHSR-1a receptor in the brain. This interaction with GHSR-1a leads to a GH release from the pituitary gland, influencing several anabolic processes, including appetite regulation, fat processing, and overall energy usage. Studies have shown that Ipamorelin can be found in the gastrointestinal tract, heart, lungs, kidney, pancreas, liver, immune cells, and adipose tissue. Glycine is one of the stimulatory agents inducing the pituitary gland to secrete HGH.
- Improvements in wellbeing and libido.
- Augmented restful sleep leads to better cognitive functions.
- Refined skin tone with stronger hair and nails.
- Decrease in mean systolic blood pressure.
- Improvement in fat loss and lean mass gains.
- Increased endurance and strength.